Mathematisch-Naturwissenschaftliche Fakultät

Institut für Biowissenschaften

Fachgebiet: Zoologie/ Tropenmedizin

Betreuer: Prof. Dr. Emil C. Reisinger

Dipl.-Biol. Martha Holtfreter
(e-mail: )

Schistosoma mansoni SAMBON, 1907 (Plathelminthes, Digenea) – Development of novel therapeutic and diagnostic approaches

Intestinal schistosomiasis, along with malaria, is one of the most prevalent parasitic diseases in tropical and sub-tropical regions, and leads to a generalized morbidity due to the chronic inflammation of the intestinal tract and the liver. The present work investigated the schistosomicidal potential of a “drug targeting” model and of the antimalarials mefloquine and primaquine. Additionally, the suitability of confocal laser scanning microscopy (CLSM) as a diagnostic tool was evaluated. The experiments demonstrated a clear dose and time dependent schistosomicidal effect of albumin- and polyethylenglycol-conjugates, as well as mefloquine and primaquine on different developmental stages of S. mansoni. Furthermore, CLSM visualises schistosomal eggs directly within gut tissue and permits determination of egg viability.