Mathematisch-Naturwissenschaftliche Fakultät

Institut für Biowissenschaften

Fachgebiet: Biophysik

Betreuer: Prof. Dr. Jan Gimsa

Dipl.-Ing. (FH), M.Sc. Kathrin Badstübner
(e-mail: )

Functional and morphological long-term effects of deep brain stimulation electrodes with two modifications in the rat 6-OHDA-hemiparkinson model

Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson’s disease, even though it is not yet fully understood. For the first time, a model for the chronic instrumentation of rats has been developed that allows for the study of DBS-effects with completely free-moving rats for up to 6 weeks.

The model was used in a comparative study with uni- and bipolar platinum/iridium-electrodes inserted into the subthalamic nucleus (STN) of 6-hydroxydopamin-induced hemiparkinsonian rats. DBS was applied using portable stimulators (130 Hz, 200 µA and 60 µs -needle pulses).

Lesion- and DBS-related effects on motor function and anxiety behavior were quantified with four different behavioral tests.

Persistent beneficial DBS-effects on lesion-induced akinesia and sensorimotor neglect were found in the stepping- and corridor-tests.

Electrical impedance spectroscopy allowed for the characterization of the electrode-encapsulation process.